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                            <h2>张晓云</h2>
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                <ul style="list-style-type: none;" class=" list-paddingleft-2"><li><p style="text-align:center"><img src="../../hdupf/img/202106/202106161623834179553388.jpg" width="230" height="307" border="0" vspace="0" title="" alt="" style="width: 230px; height: 307px;"/></p></li><li><p><br/></p></li><li><p style="text-align: left;">职务/职称：副教授/硕导</p></li><li><p style="text-align: left;">研 究 所：药剂学研究所</p></li><li><p style="text-align: left;">联系电话：</p></li><li><p style="text-align: left;">电子邮件：pharmacyzxy@163.com; zhangxiaoy@lzu.edu.cn</p></li><li><p style="text-align: left;">办 公 室：勤博楼3005室</p></li></ul><p><br style="text-align: left;"/></p><ul style="list-style-type: none;" class=" list-paddingleft-2"><li><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【基本情况】<br style="box-sizing: border-box; text-align: left;"/>　　 博士，副教授，硕士研究生导师。教育部学位论文评审专家。2010年毕业于中国药科大学并获得理学博士学位，同年被评聘为副教授；2010年-2011年Florida University 访问学习。现担任Journal of Microencapsulation, Colloids and Surfaces B: Biointerfaces,&nbsp; Macromolecule等杂志的审稿人。<br style="box-sizing: border-box; text-align: left;"/>【研究方向】<br style="box-sizing: border-box; text-align: left;"/>　　主要从事药物处方前研究与剂型设计、新型给药传输系统的研究、靶向制剂及其动物体内动力学的研究、剂型改造、制剂新技术与新剂型的研究、药物与药物制剂稳定性研究。<br style="box-sizing: border-box; text-align: left;"/>【主讲课程】<br style="box-sizing: border-box; text-align: left;"/>　　《药剂学》、《生物药剂学与药物动力学》、《体内药物代谢动力学》、《药剂学实验》、《生物药剂学与药物动力学实验》<br style="box-sizing: border-box; text-align: left;"/>【获奖情况】<br style="box-sizing: border-box; text-align: left;"/>　　2011年度甘肃省科学技术进步奖二等奖；2014年兰州大学大学生创新创业行动计划“优秀指导教师”；2015年获兰州大学“大学生创新优秀指导教师”；兰州大学医学院2015年本科实践教学优秀指导教师； 兰州大学2016年度“隆基教育教学新秀奖”； 兰州大学2016年度“兰州大学本科毕业论文（设计）优秀指导教师”；兰州大学2016年度“兰州大学创新创业项目优秀指导教师”三等奖；2017年度甘肃省药学发展奖二等奖。<br style="box-sizing: border-box; text-align: left;"/></p></li></ul><p><br style="text-align: left;"/></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【1】Xiaoyun Zhang, Hua Qiao, Jingman Ni, Yanbin Shi, Yin Qiang. Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice. European Journal of Pharmaceutical Sciences, 49 (2013) 411–422.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【2】Xiao Yun Zhang, Hua Qiao, Yan Bin Shi, An HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics. Pharm Biol, 2014;52(1):21-30.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【3】Xiaoyun Zhang, Hua Qiao, Peng Zhao, Jingman Ni, Yanbin Shi. Antitumor activity and biodistribution of DHA-NLC formulation in sarcoma 180-bearing mice, Journal of Chinese Pharmaceutical Sciences, 22 (2013) 348-354.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【4】张晓云, 赵 鹏，乔 华, 倪京满, 史彦斌. 双氢青蒿素纳米结构脂质载体抗肿瘤作用的研究,中国新药杂志，22 (17) (2013): 87-91.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【5】张晓云, 赵鹏，乔华, 倪京满, 史彦斌. 双氢青蒿素磷脂复合物的研究,中国现代应用药学杂志，30 (6) (2013) : 636-641.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【6】Hua Qiao, Xiaoyun Zhang, Ting Wang, Li Liang, Wei Chang. Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration. Pharmaceutical biology, 2014;52(2):228-36.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【7】Xiaoyun Zhang, Hua Qiao, Taifeng Zhang, Yanbin Shi, Jingman Ni. Enhancement of gastrointestinal absorption of isoliquiritigenin by nanostructured lipid carrier. Advanced Powder Technology 25 (2014) 1060–1068.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【8】 Lin LI, Xiaoyun ZHANG*(通讯), Ying CHEN, Jieqiong YOU, Hua QIAO, Jixin LIU, Yanbin SHI, Xiaoning ZHAO. Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles, Latin American Journal of Pharmacy. Lat. Am. J. Pharm. (2015) 34 (4): 773-781.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【9】Xiaoyun Zhang, Ying Chen, Lin Li,Hua Qiao,Rui Wang, Jingman Ni*,Jieqiong You, Kaikai Ma, Chenchen Fan, Quan Fang. Development 1 and validation of a reversed phase liquid chromatographic method with fluorescence detection for the pharmacokinetic study of a new chimeric peptide, Analytical Methods, 2016,8: 2620–2627.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【10】 Xiaoyun Zhang, Hua Qiao, Ying Chen, et al. Preparation, properties and preclinical pharmacokinetics of low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle, Iranian Journal of Pharmaceutical Research, 2016,15(3): 269-282.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【11】靳婷,罗冰峰,张晓云*,李文斌,张娟红,张明霞,王昌,赵安鹏,王荣. 缺氧对大鼠6种药物转运体基因表达影响的差异性研究, 《解放军药学学报》 2017, 33 (4):297-301.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【12】Yanbin Shi, Xiaoyun Zhang, Jianyong Li, Zuoneng Wang, Sen Cheng, Ligang Chen, Yin Qiang, Huili Li, Jingman Ni. Preparation and pharmacokinetics of an injectable thermosensitive hydrogel of diminazene aceturate. J. DRUG DEL. SCI. TECH., 2013,23 (6) 531-536.&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px;"><br style="box-sizing: border-box; text-align: left;"/></p><ul style="list-style-type: none;" class=" list-paddingleft-2"><li><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px;"><br style="text-align: left;"/></p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【1】甘肃省科技计划（1304FKCA073）：新型镇痛肽BN-9体内动力学性质及其生物组织分布特征研究，项目负责人；&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【2】兰州市科技计划项目（2012-2-80）：双氢青蒿素纳米结构脂质载体冻干粉的制备及其抗肿瘤作用的研究，项目负责人；&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【3】国家自然科学基金项目(纵20170147)：采用分子桥键化等策略构建高效稳定的α-螺旋型抗菌肽构效关系研究，参与；&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【4】国家自然科学基金项目(纵20170140)：肿瘤细胞内可顺次诱导激活的肉桂醛基功能有机分子的合成、组装及其抗肿瘤研究，参与&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【5】国家自然科学基金项目(81273440)：高稳定性酸敏感穿膜肽的设计与应用，参与&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【6】国家自然科学基金项目(21301081)：智能型“酶-抗癌前药”联合传输多功能介孔纳米载药系统的构建及评价，参与&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【7】甘肃省自然科学基金项目(1506RJYA221)：活性氧自由基控释体系的构建及其抗肿瘤研究，参与&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【8】横向项目(0462(11))：异甘草素微囊缓释片，负责人&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px; text-align: left;">【9】基本科研业务费-自由探索项目(lzujbky-2012-85)：肿瘤靶向双氢青蒿素纳米结构脂质载体、动物体内的药动学及其抗肿瘤药效学研究，负责人&nbsp;</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 0px; margin-block: 0.1em; list-style: none; padding: 0px;"><br style="box-sizing: border-box; text-align: left;"/></p></li></ul><p><br style="text-align: left;"/></p>            </div>
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