杨东旭
杨东旭，男，汉族，理学博士。兰州大学基础医学院教授。2009年于兰州大学生命科学院获得学士学位，2015年于兰州大学生命科学院获得博士学位，师从王锐院士。目前研究工作集中于发展金属镁催化策略的手性物质合成，包括活性分子和非天然氨基酸的高效构建以及其在多肽药物中的应用。 现已发表学术论文40余篇。多篇论文发表在国际著名期刊包括Chem., Angew. Chem. Int. Ed., Chem. Sci., Chem. Rev., Org. Lett., ACS. Catalysis., Chem. Eur. J. 等。论文总引用1000余次，H index 21 (GS)。
研究方向：手性物质科学，不对称合成。小分子与多肽分子药物。
代表性论文
1. Dongxu Yang*, Linqing Wang, Dan Li, and Rui Wang*, Chem. 2019, DOI: 10.1016/j. chempr. 2019. 02. 002. (IF = 14.104).
2. Linqing Wang, Dongxu Yang*, Dan Li, Xihong Liu, Pengxin Wang, Kezhou Wang, Haiyong Zhu, Lutao Bai, and Rui Wang*, The Important Role of the Byproduct Triphenylphosphine Oxide in the Magnesium(II)-Catalyzed Enantioselective Reaction of Hemiacetals and Phosphorus Ylides. Angew. Chem. Int. Ed. 2018, 57, 9088-9092. (IF = 12.102).
3. Dongxu Yang,1 Linqing Wang,1 Ming Kai,1 Dan Li, Xiaojun Yao, and Rui Wang*, Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of β-Naphthols. Angew. Chem. Int. Ed. 2015, 54, 9523-9527. (IF = 12.102).
4. Dongxu Yang,1 Linqing Wang,1 Fengxia Han, Dan Li, Depeng Zhao, and Rui Wang*, Intermolecular Enantioselective Dearomatization Reaction of bNaphthol Using meso-Aziridine: A Bifunctional In Situ Generated Magnesium Catalyst. Angew. Chem. Int. Ed. 2015, 54, 2185-2189. (封面文章, IF = 12.102).
5. Dongxu Yang, Linqing Wang, Fengxia Han, Depeng Zhao, Bangzhi Zhang, and Rui Wang*, Direct Site-Specific and Highly Enantioselective g-Functionalization of Linear a,b-Unsaturated Ketones: Bifunctional Catalytic Strategy. Angew. Chem. Int. Ed. 2013, 52, 6739-6742. (IF = 12.102).
6. Jie Wang, Pengxin Wang, Linqing Wang, Dan Li, Kezhou Wang, Yuan Wang, Haiyong Zhu, Dongxu Yang *, and Wang R*. Nickel-Mediated Asymmetric Allylic Alkylation between Nitroallylic Acetates and Acyl Imidazoles. Org. Lett. 2017, 19, 4826-4829. (IF = 6.492).
7. Dan Li, Kezhou Wang, Linqing Wang, Yuan Wang, Pengxin Wang, Xin Liu, Dongxu Yang*, and Rui Wang*, Magnesium Catalysis Mediated Tetrazoles in Desymmetrization Reaction of Aziridines. Org. Lett. 2017, 19, 3211-3214. (SCI一区，IF = 6.492).
8. Kezhou Wang, Linqing Wang, Xihong Liu, Dan Li, Haiyong Zhu, Pengxin Wang, Yuyang Liu, Dongxu Yang*, and Rui Wang*, Development of Biligands Magnesium Catalysis in Asymmetric Conjugate Reactions of C3-Pyrrolyl-Oxindoles. Org. Lett. 2017, 19, 4351-4354. (IF = 6.492).
The Important Role of the Byproduct Triphenylphosphine Oxide in the
Magnesium(II)-Catalyzed EnantioselectiveReaction of Hemiacetals
and PhosphorusYlides
The Important Role of the Byproduct Triphenylphosphine Oxide in the
Magnesium(II)-Catalyzed EnantioselectiveReaction of Hemiacetals
and PhosphorusYlides
The Important Role of the Byproduct Triphenylphosphine Oxide in the
Magnesium(II)-Catalyzed EnantioselectiveReaction of Hemiacetals
and PhosphorusYlides
9. Dan Li, Yijie Wang, Linqing Wang, Jie Wang, Pengxin Wang, Kezhou Wang, Li Lin, Dongsheng Liu,* Xianxing Jiang* and Dongxu Yang*, Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines. Chem. Commun. 2016, 52, 9640-9643. (封面文章, SCI一区，IF = 6.290).
10. Linqing Wang, Dongxu Yang*, Dan Li, Pengxin Wang, Kezhou Wang, Jie Wang, Xianxing Jiang,* and Rui Wang*, MgII-Mediated Catalytic Asymmetric Dearomatization (CADA) Reaction of b-Naphthols with Dialkyl Acetylenedicarboxylates. Chem. Eur. J. 2016, 22, 8483-8487. (IF = 5.160). ApplicationofaCCBond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of b-Naphthols.
11. Xihong Liu , Yijie Wang, Dongxu Yang, Jinlong Zhang, Dongsheng Liu*, and Wu Su*, Catalytic Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Azlactones: Access to Chiral Tricyclic Tetrahydroisoquinolines. Angew. Chem. Int. Ed. 2016, 55, 8100-8103. (IF = 12.102).
12. Liang Hong, Wangsheng Sun, Dongxu Yang, Guofeng Li, and Rui Wang*, Additive Effects on Asymmetric Catalysis. Chem. Rev. 2016, 116, 4006-4123. (IF = 52.613).
13. Dan Li,? Linqing Wang,? Dongxu Yang, Bangzhi Zhang,* and Rui Wang*, Catalytic Desymmetrization of meso-Aziridines with Benzofuran2(3H) Ones Employing a Simple In Situ-Generated Magnesium Catalyst. ACS Catal. 2015, 5, 7432-7436. (IF = 11.384).
14. Depeng Zhao, Linqing Wang, Dongxu Yang, Yixin Zhang, and Rui Wang*, Highly Diastereo- and Enantioselective Synthesis of α-Alkyl Norstatine Derivatives: Catalytic Asymmetric Mannich Reactions of 5H-Oxazol-4-ones. Angew. Chem. Int. Ed. 2012, 51, 7523-7527. (IF = 12.102).
15. Depeng Zhao, Dongxu Yang, Yijie Wang, Yuan Wang, Linqing Wang, Lijuan Mao, and Rui Wang*, Enantioselective Mannich reaction of a highly reactive Horner–Wadsworth– Emmons reagent with imines catalyzed by a bifunctional thiourea. Chem. Sci. 2011, 2, 1918-1921. (IF = 9.063).