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                            <h2>刘晓菊</h2>
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                <p style="text-align:center"><img width="207" height="277" title="" style="width: 207px; height: 277px;" alt="" src="../../hdupf/img/202209/202209151663225753119714.jpg" border="0" vspace="0"/></p><table width="100%" cellspacing="0" cellpadding="0"><tbody><tr class="firstRow"><td style="font-size: 14px; margin: 0px; padding: 0px;"><blockquote style="border: 0px; outline: 0px; font-weight: inherit; font-style: inherit; font-family: inherit; vertical-align: baseline; margin: 0px; padding: 0px; quotes: &quot;&quot; &quot;&quot;; text-indent: 2em; text-align: left;"><blockquote style="border: 0px; outline: 0px; font-weight: inherit; font-style: inherit; font-family: inherit; vertical-align: baseline; margin: 0px; padding: 0px; quotes: &quot;&quot; &quot;&quot;; text-align: left;"><p style="border: 0px; outline: 0px; font-weight: inherit; font-style: inherit; font-family: inherit; vertical-align: baseline; text-align: left;"><span style="border: 0px; outline: 0px; font-weight: inherit; font-style: inherit; vertical-align: baseline; margin: 0px; padding: 0px; line-height: 2; font-family: 宋体, SimSun; font-size: 16px;"></span></p><p style="text-indent:32px;line-height:27px"><span style="font-size:16px;font-family:&amp;#10">【基本情况】</span></p><p style="text-indent:32px;line-height:27px"><span style="font-size:16px;font-family:&amp;#10">刘晓菊，教授，前副院长，老年呼吸科，专业型和学术型博士研究生导师、专业型和学术型硕士研究生导师。享受国务院政府特殊津贴专家、甘肃省领军人才、兰州大学名师奖获得者、全国三八红旗手。</span></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:黑体">&nbsp;</span></strong></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:黑体">【学习经历】</span></strong></p><p style="margin-left:0;text-indent:32px;line-height:150%"><span style="font-size:16px;line-height:&#10;font-family:宋体">1980.09-1985.08 </span><span style="font-size:16px;line-height:150%;font-family:宋体">西安医科大学临床医学系 医学学士</span></p><p style="text-indent:32px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:宋体">1990.09-1994.06 </span><span style="font-size:16px;line-height:150%;font-family:宋体">兰州医学院内科（呼吸）硕士研究生 医学硕士</span></p><p style="margin-left:14px;text-indent:16px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:宋体">2000.09-2003.06 </span><span style="font-size:16px;line-height:150%;font-family:宋体">兰州大学生命科学院博士研究生 理学博士</span></p><p style="text-indent:32px;line-height:27px"><span style="font-size:16px;font-family:宋体">&nbsp;</span></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">【工作经历】</span></strong></p><p style="margin-left:14px;text-indent:16px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:宋体">1985.08-1993.11 </span><span style="font-size:16px;line-height:150%;font-family:宋体">兰州医学院第一附属医院内科 住院医师</span></p><p style="margin-left:14px;text-indent:16px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:宋体">1993.12-1997.09 </span><span style="font-size:16px;line-height:150%;font-family:宋体">兰州医学院第一附属医院呼吸科 主治医师</span></p><p style="margin-left:14px;text-indent:16px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:宋体">1997.10-2002.10 </span><span style="font-size:16px;line-height:150%;font-family:宋体">兰州医学院第一附属医院呼吸科 副主任医师、副教授</span></p><p style="text-indent:32px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:宋体">2002.11</span><span style="font-size:16px;line-height:150%;font-family:宋体">—2006.05 兰州大学第一医院呼吸科 主任医师、副教授</span></p><p style="text-indent:32px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:宋体">2006.06—</span><span style="font-size:16px;line-height:150%;font-family:宋体">至今&nbsp;&nbsp;&nbsp; 兰州大学第一医院老年呼吸科 教授、主任医师</span></p><p style="text-indent:32px;line-height:27px"><span style="font-size:16px;font-family:宋体">&nbsp;</span></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">【目前承担课程】</span></strong></p><p style="text-indent:32px;line-height:27px"><span style="font-size:16px;font-family:宋体;color:#333333;background:white">《内科学》甘肃省精品课程（呼吸系统疾病）的大课讲授、临床实习带教。</span></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">&nbsp;</span></strong></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">【主要科研成果】</span></strong></p><p style="line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">研究方向：</span></strong></p><p style="margin-left:72px;line-height:27px"><span style="font-size:16px;font-family:" tahoma="">1.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;font-family:" tahoma="">大气污染与慢性气道疾病的关系</span></p><p style="margin-left:72px;line-height:27px"><span style="font-size:16px;font-family:" tahoma="">2.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;font-family:" tahoma="">自由基与慢性气道疾病</span></p><p style="margin-left:72px;line-height:27px"><span style="font-size:16px;font-family:" tahoma="">3.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;font-family:" tahoma="">慢阻肺、哮喘发病机制的研究</span></p><p style="line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">主持或参与科研项目：</span></strong></p><p style="margin-left:48px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">1.<span style="font:9px " new="" times="">&nbsp; </span></span></strong><span style="font-size:16px;font-family:" tahoma="">《PM2.5致慢性阻塞性肺疾病免疫失衡的miRNA/Notch调控机制研究》，2019国家自然科学基金地区基金 (81960009)，第一主持人</span></p><p style="margin-left:48px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">2.<span style="font:9px " new="" times="">&nbsp; </span></span></strong><span style="font-size:16px;font-family:" tahoma="">《PM2.5影响微丝重排加剧慢性阻塞性肺疾病肺泡巨噬细胞吞噬缺陷的机制研究》，2016国家自然科学基金面上项目（81670033），第一主持人</span></p><p style="margin-left:48px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">3.<span style="font:9px " new="" times="">&nbsp; </span></span></strong><span style="font-size:16px;font-family:" tahoma="">《慢性阻塞性肺疾病患者巨噬细胞吞噬功能缺陷机制的研究》，2010国家自然科学基金面上项目（81070038），第一主持人</span></p><p style="margin-left:48px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">4.<span style="font:9px " new="" times="">&nbsp; </span></span></strong><span style="font-size:16px;font-family:" tahoma="">《PM2.5对哮喘急性发作的影响及机制研究》，2017甘肃省重点研发计划项目（17YF1FA129），第一主持人</span></p><p style="line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">&nbsp;</span></strong></p><p style="line-height:150%"><strong><span style="font-size:16px;line-height:150%;font-family:" tahoma="">发表主要论文或专著:</span></strong></p><p style="margin-left:48px;line-height:&#10;text-autospace:none"><strong><span style="font-size:16px;line-height:150%;font-family:" tahoma="">1.<span style="font:9px " new="" times="">&nbsp; </span></span></strong><strong><span style=";line-height:150%">Xiaoli Zeng, Xiaoju Liu* and HairongBao, Sulforaphane suppresses lipopolysaccharide- and Pam3CysSerLys4-mediated inflammation in chronic obstructive pulmonary disease via toll-like receptors, FEBS, 2021(11): 1313-1321. (</span></strong><strong><span style=";line-height:150%;font-family:宋体">通讯作者</span></strong><strong><span style=";line-height:150%">) </span></strong></p><ol class=" list-paddingleft-2" type="1" style="margin-top:0" start="2"><li><p><strong><span style=";line-height:150%">Zhen He, Jirong Wu, Xiaoli Zeng, HairongBao, Xiaoju Liu*, Role of the &nbsp; &nbsp; &nbsp;Notch ligands&nbsp; Jagged1 and Delta4 in &nbsp; &nbsp; &nbsp;Th17/Treg immune imbalance in a mouse model of chronic asthma, &nbsp; &nbsp; &nbsp;Experimental Lung Research, May-Aug 2021, 47(6)</span></strong><strong><span style=";line-height:150%;font-family:宋体">：</span></strong><strong><span style=";line-height:150%">289-299. (</span></strong><strong><span style=";line-height:150%;font-family:宋体">通讯作者</span></strong><strong><span style=";line-height:150%">)</span></strong><a name="OLE_LINK20"></a><a name="_Hlk78476265"></a></p></li><li><p><strong><span style=";line-height:150%">Xin Li and Xiaoju Liu</span></strong><strong><span style=";line-height:150%">*, <a name="OLE_LINK7"></a><a name="OLE_LINK6"></a>Effects of PM2.5 on &nbsp; &nbsp; &nbsp;Chronic Airway Diseases: A Review of Research Progress, &nbsp; &nbsp; &nbsp;Atmosphere, </span></strong><strong><span style=";line-height:150%">2021, 12(8), 1068: 1-12.&nbsp; (</span></strong><span style="font-family:宋体">通讯作者</span><span style="font-family:" new="" times="">)</span></p></li><li><p><strong><span style=";line-height:150%">Bao HR, Chen JL, Liu XJ*, Relationship between PI3K/mTOR/RhoA &nbsp; &nbsp; &nbsp;pathway-regulated cytoskeletal rearrangements and phagocytic capacity of &nbsp; &nbsp; &nbsp;macrophages, the Brazilian Journal of Medical and Biological Research, &nbsp; &nbsp; &nbsp;2020 Jun 3; 53(7): e9207. (</span></strong><strong><span style=";line-height:150%;font-family:宋体">通讯作者</span></strong><strong><span style=";line-height:150%">)</span></strong></p></li><li><p><strong><span style=";line-height:150%">Gu X-Y, Chu X, Zeng XL, &nbsp; &nbsp; &nbsp;Bao HR</span></strong><strong><span style=";line-height:150%;font-family:宋体">，</span></strong><strong><span style=";line-height:150%">Liu XJ*</span></strong><strong><span style=";line-height:150%;font-family:宋体">，</span></strong><strong><span style=";line-height:150%">Effects of &nbsp; &nbsp; &nbsp;PM2.5 exposure on the Notch signaling pathway and immune imbalance in &nbsp; &nbsp; &nbsp;chronic obstructive pulmonary disease</span></strong><strong><span style=";line-height:150%;font-family:宋体">，</span></strong><strong><span style=";line-height:150%">Environ &nbsp; &nbsp; &nbsp;Pollu</span></strong><strong><span style=";line-height:150%;font-family:宋体">，</span></strong><strong><span style=";line-height:150%">2017 July, &nbsp; &nbsp; &nbsp;226:163-173. </span></strong><strong><span style=";line-height:150%;font-family:宋体">（通讯作者）</span></strong></p></li><li><p><strong><span style=";line-height:150%">Liu XJ, <a name="OLE_LINK24"></a><a name="OLE_LINK23"></a>Bao HR, &nbsp; &nbsp; &nbsp;Zeng XL, Wei JM. Effects of resveratrol and genistein on nuclear &nbsp; &nbsp; &nbsp;factor-κB, tumor necrosis factor-α and matrix metalloproteinase-9 in &nbsp; &nbsp; &nbsp;patients with chronic obstructive pulmonary disease. Mol Med Rep. 2016 &nbsp; &nbsp; &nbsp;May;13(5):4266-4272.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; &nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></strong></p></li><li><p><strong><span style=";line-height:150%">Bao HR, Liu XJ*, Li YL, &nbsp; &nbsp; &nbsp;Men X, Zeng XL. Sinomenine attenuates airway inflammation and remodeling &nbsp; &nbsp; &nbsp;in a mouse model of asthma. Mol Med Rep. 2016 Mar;13(3):2415-2422. (</span></strong><strong><span style=";line-height:150%;font-family:宋体">通讯作者</span></strong><strong><span style=";line-height:150%">) </span></strong></p></li><li><p><strong><span style=";line-height:150%">Chu X, Liu XJ*, Qiu JM, &nbsp; &nbsp; &nbsp;Zeng XL, Bao HR, Shu J. Effects of Astragalus and Codonopsispilosula<a name="OLE_LINK15"></a>polysaccharides on alveolar macrophage phagocytosis and &nbsp; &nbsp; &nbsp;inflammation in chronic obstructive pulmonary disease mice exposed to &nbsp; &nbsp; &nbsp;PM2.5. Environ ToxicolPharmacol. 2016 Dec;48:76-84.&nbsp;(</span></strong><strong><span style=";line-height:150%;font-family:宋体">通讯作者</span></strong><strong><span style=";line-height:150%">)</span></strong></p></li><li><p><strong><span style=";line-height:150%;font-family:宋体">李娜,师萌,刘凯, 曾晓丽, 包海荣, 刘晓菊. JAK/STAT信号通路在慢性阻塞性肺疾病Th17/Treg免疫失衡中的作用,中华结核和呼吸杂志, 2022, 45(7):71-76.<a name="_GoBack"></a>（通讯作者）</span></strong></p></li><li><p><strong><span style=";line-height:150%;font-family:宋体">曾晓丽, 施凯, 庞琪, 包海荣, 刘晓菊. PM2.5 对慢性阻塞性肺疾病患者巨噬细胞 Toll 样受体表达及吞噬功能的影响，中国免疫学杂志，2022,38(6):720-724.（通讯作者）</span></strong></p></li></ol><p style="line-height:27px"><span style="font-size:16px;font-family:" tahoma="">&nbsp;</span></p><p style="text-indent:32px;line-height:150%"><strong><span style="font-size:16px;line-height:150%;font-family:&amp;#10">【社会兼职和社会服务】</span></strong></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">1.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">中华医学会呼吸病学分会全国常委</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">2.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">中华医学会呼吸病学分会慢阻肺学组副组长</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">3.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">国家呼吸专科医疗质量控制中心专家委员会委员</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">4.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">全国结核病防治综合质量控制专家委员会委员</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">5.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">中华预防医学会呼吸病预防与控制专委会常委</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">6.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">中华预防医学会老年病预防专委会委员</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">7.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">中国老年医学学会呼吸病学分会委员</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">8.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">中国康复医学会呼吸康复专委会常委</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">9.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">中国老年医学学会舒缓医学分会常委</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">10.</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">甘肃省医学会呼吸病与结核病分会主任委员</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">11.</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">甘肃省呼吸疾病临床研究中心主任</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">12.</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">甘肃省呼吸重症质控中心主任</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">13.</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">甘肃省呼吸重症医联体主任</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">14.</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">甘肃省结核病防治综合质量控制专家委员会主任委员</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">15.</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">甘肃省基层呼吸疾病防治联盟主席</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">16.</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">甘肃省医师协会呼吸医师分会副会长</span></p><p style="margin-left:56px;text-indent:0;line-height:150%"><strong><span style="font-size:16px;line-height:&#10;font-family:" tahoma="">&nbsp;</span></strong></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">【获奖情况】</span></strong></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">1.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">慢性气道疾病的防治及大气污染物PM2.5对其影响的系列研究，2019年度甘肃省科技进步奖二等奖，第一完成人</span></p><p style="margin-left:56px;line-height:&amp;#10"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">2.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">慢性气道疾病及大气污染物对其影响的系列研究，2017年获甘肃医学科技奖一等奖，第一完成人</span></p><p style="margin-left:56px;line-height:150%"><span style="font-size:16px;line-height:150%;font-family:" tahoma="">3.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">64</span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">层螺旋CT血管成像对急慢性肺栓塞诊断及治疗的临床评价，2014年获兰州市科学技术进步奖二等奖，第三完成人</span></p><p style="margin-left:56px;text-align:left;line-height:150%"><span style=";line-height:150%;font-family:楷体_GB2312">4.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;line-height:150%;font-family:" tahoma="">三种生理病理状态下人体的氧化应激和抗氧化剂作用的系列研究，<a name="OLE_LINK5"></a><a name="OLE_LINK4"></a>2009年获甘肃科技进步奖三等奖，第一完成人</span></p><p style="margin-left:56px;line-height:27px"><span style="font-size:16px;font-family:" tahoma="">5.<span style="font:9px " new="" times="">&nbsp; </span></span><span style="font-size:16px;font-family:" tahoma="">三种生理病理状态下人体的氧化应激和抗氧化剂作用的系列研究，2009年获甘肃医学科技奖二等奖，第一完成人</span></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">&nbsp;</span></strong></p><p style="text-indent:32px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">【联系方式】</span></strong></p><p style="text-indent:48px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">办公电话：</span></strong><span style="font-size:16px;font-family:" tahoma="">0931-8356023</span></p><p style="text-indent:48px;line-height:27px"><strong><span style="font-size:16px;font-family:" tahoma="">E-mail</span></strong><strong><span style="font-size:16px;font-family:" tahoma="">：</span></strong><span style="font-size:16px;font-family:" tahoma="">liuxiaoju835@126.com</span></p><p style="border: 0px; 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